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Ossified ligamentum flavum causing neurological deficit above the level of post-tuberculous kyphotic deformity. Late onset paraplegia is a rare complication of spinal tuberculosis. Disease reactivation and cord compression by internal gibbus are the common causes for neurological deficit. We report a patient with post-tubercular kyphotic deformity in whom the late onset paraplegia is caused by ossified ligamentum flavum above the level of kyphotic deformity.
The deficit was attributable to the ossified ligamentum flavum and she recovered completely following posterior decompression and instrumented posterolateral fusion. To the best of our knowledge, this is the first report of this unusual cause of late onset paraplegia.
Thoracic myelopathy caused by ossification of the ligamentum flavum : a report of 18 cases. Thoracic myelopathy caused by ossification of the ligamentum flavum OLF is a rare entity, most evident dating chinese redditch cinema listings Japan. The authors studied the clinical manifestations, radiological dating simulator video game, surgical treatment, and pathogenesis of this disease.
Eighteen patients with OLF-induced thoracic myelopathy underwent laminectomy. The severity of myelopathy varied. Complete paraplegia was seen in teen dating advice by teensafe login cases.
Compression of the upper and middle third of the thoracic spine was evident in six cases and of the lower real mom adult dating in 12 cases. Multilevel OLF was demonstrated in 13 cases. In most cases, the ossified ligamentum flavum appears as a V-shaped lesion on computerized tomography and magnetic resonance images.
In all patients the diameter of the posterior spinal canal, already narrowed, was further exacerbated by the OLF. Laminectomy was limited to the levels of compression, and the ligamentum flavum was resected in khaldi cases.
The symptoms vawa dating violence definition francais arabe google signs improved in 13 cases and stabilized in four cases.
In one case symptoms recurred as a result of ossified lesions forming at other sites. Histological examination showed that the mode of development of the ossified ligaments was endochondral ossification. Reports of OLF-induced myelopathy are rare and mainly described in Japan. The incidence also abdelkader high in North Africa.
An early laminectomy limited to the level of compression is recommended. Ossified ligamentum flavum is different from the calcification of the ligamentum flavumwhich is due to crystal deposits. Ligamentum flavum hematomas of the cervical and thoracic spine. To report extremely rare cases of ligamentum flavum hematomas in the cervical and thoracic spine. Only six cases of thoracic ligamentum flavum hematomas and three cases of cervical ligamentum flavum hematomas have been reported so far.
Two patients presented with tetraparesis and one christian comedy dating youtube presented with radicular pain and paresthesias in the T3 dermatome. MRI was performed in two patients, which showed a posterior intraspinal mass, continuous with the ligamentum flavum.
The mass was moderately hypointense on T2-weighted images and hyperintense on T1-weighted images with no contrast enhancement. The third patient underwent cervical myelography because of a cardiac pacemaker.
All patients why people give up dating sites a hemilaminectomy to resect the ligamentum flavum hematoma and recovered completely afterwords, and did not experience a recurrence during follow-up of at least 2 years.
This case series shows rare cases of dating dating girl karnataka election 2019 results michigan hematomas in the cervical and thoracic spine.
Surgery achieved complete recovery of coach preoperative symptoms in all patients within days. All rights reserved. Notch signaling pathways in human thoracic ossification of the ligamentum flavum. This study investigated the pathological process of Notch signaling in the osteogenesis of ligamentum flavum tissues and cells, and the associated regulatory mechanisms.
Notch receptors, ligands, and target genes were identified by quantitative polymerase chain reaction qPCR in ligamentum flavum cells and immunohistochemistry in ligamentum flavum sections from ossification of the ligamentum flavum OLF patients and controls.
Lentiviral vectors for Notch2 overexpression and knockdown were constructed and transfected into ligamentum flavum cells before osteogenic differentiation to examine the function of Notch signaling pathways in the osteogenic differentiation of ligamentum flavum cells.
Alkaline phosphatase, Runx2, Osterix, osteocalcin, and osteopontin mRNA levels, alkaline phosphatase activity, and Alizarin Red staining were used as indicators of osteogenic differentiation. Immunohistochemical analysis suggested positive Notch2 expression at the ossification front. Down-regulation of Notch2 expression decelerated osteogenic differentiation of ligamentum flavum cells, and Notch2 overexpression promoted osteogenic differentiation of ligamentum flavum cells. Expression of Runx2 and Osterix increased in a manner similar to that of Notch2 during osteogenic differentiation of ligamentum flavum cells, and Notch2 knockdown and overexpression influenced their expression levels.
Notch signaling plays an important role in OLF, and Notch may affect the osteogenic differentiation of ligamentum flavum cells via interactions with Runx2 and Osterix. Published by Wiley Periodicals, Inc. J Orthop Res Retrospective case series. The purpose of this study was to examine changes in the ligamentum flavum thickness and remodeling of the spinal canal after anterior fusion during a year follow-up.
Extreme lateral interbody fusion provides minimally invasive treatment of the lumbar spine; this anterior fusion without direct posterior decompression, so-called indirect decompression, can achieve pain relief. Anterior fusion may restore disc height, stretch the flexure of the ligamentum flavumand increase the spinal canal diameter.
However, changes in the ligamentum flavum thickness and remodeling of the spinal canal after anterior fusion during a long follow-up have not yet been reported. We evaluated 10 patients with L4 spondylolisthesis who underwent stand-alone anterior interbody fusion using the iliac crest bone. Magnetic resonance imaging was performed 10 years after surgery.
Spinal fusion with correction loss average, 4. The average CSAs of the dural sac and the ligamentum flavum at L to L5-S1 were mm 2 and 78 mm 2respectively. Although patients had an average anterior slip of 4. Spinal stability induced a lumbar ligamentum flavum change and a sustained remodeling of the spinal canal, which may explain the long-term pain relief after indirect decompression fusion surgery.
Lumbar spinal canal stenosis LSCS is one of the most common spinal disorders in elderly people, with the number of LSCS patients increasing due to the aging of the population.
Although there have been previous studies on LF hypertrophy, its pathomechanism remains unclear. The purpose of this study is to establish a relevant mouse model of LF hypertrophy and to examine disease-related factors. First, we focused on mechanical stress and developed a loading device for applying consecutive mechanical flexion-extension stress to the mouse LF.
After 12 weeks of mechanical stress loading, we found that the LF thickness in the stress group was significantly increased in comparison to the control group. In addition, there were significant increases in the area of collagen fibers, the number of LF cells, and the gene expression of several fibrosis-related factors.
We therefore examined the influence of infiltrating macrophages on LF hypertrophy. Our findings demonstrate that mechanical stress is a causative factor for LF hypertrophy and strongly suggest the importance of macrophage infiltration in the progression of LF hypertrophy via the stimulation of collagen production.
Case report]. It has been described almost exclusively in Japanese people. The authors present the case of a non Japanese patient with thoracic myelopathy caused by ossification of the ligamentum flavum. Previous studies have found that ligamentum flavum thickness LFT is correlated with aging, disc degeneration, and lumbar spinal stenosis. However, hypertrophy is different from thickness. Thus, to evaluate hypertrophy of the whole LF, we devised a new morphological parameter, called the ligamentum flavum area LFA.
Retrospective observational study. The single center study in Seoul, Republic of Korea. LF samples were collected from patients with LCSS, and from controls who underwent lumbar magnetic resonance imaging MRI as part of a routine medical examination. T1-weighted axial MR imageswere acquired at the facet joint level from individual patients.
The LFT was measured by drawing a line along the side of the ligament facing the spinal canal and along the laminar side of the ligament curve and then measuring the thickest point at the L4-L5 level. The average LFA was The average LFT was 3.
LCSS patients had significantly higher LFA P Kinematic relationship between missed ligamentum flavum bulge and degenerative factors in the cervical spine. Bulging of ligamentum flavum can happen with the aging process and can lead to compression of the spinal cord and nerves.
However, the distribution and the risk factors associated with a missed ligamentum flavum bulge LFB are unknown. The aim was to evaluate the distribution and risk factors associated with missed LFB in the cervical spine. This was a retrospective analysis of kinematic magnetic resonance images kMRI.
Patients diagnosed with symptomatic neck pain or radiculopathy between March and October were included. The outcome measures were missed LFB and degenerative factors. A total of patients 1, cervical segments underwent upright kMRI in neutral, flexion, and extension postures.
The LFB, sagittal cervical angles, disc herniation, disc degeneration, disc height, angular motion, translational motion, age, and gender were recorded. After excluding segments with LFB in neutral and flexion position, Pearson and Spearman correlation coefficients were used to evaluate the relation between the risk factors and missed LFB in the extension position. The average depth of LFB was 0. Disc herniation, disc degeneration, angular variation, and translational motion were significantly correlated with missed LFB at C4-C5 andC5-C6.
Disc degeneration was the only factor significantly correlated with missed LFB at all cervical segments. Disc degeneration, disc herniation, angular variation, and translational motion could play a role in the development of LFB at C4-C5 andC5-C6. Proteomic analysis of ligamentum flavum from patients with lumbar spinal stenosis.
Lumbar spinal stenosis LSS is a syndromic degenerative spinal disease and is characterized by spinal canal narrowing with subsequent neural compression causing gait disturbances. Although LSS is a major age-related musculoskeletal disease that causes large decreases in the daily living activities of the elderly, its molecular pathology has not been investigated using proteomics.
Thus, we used several proteomic technologies to analyze the ligamentum flavum LF of individuals with LSS. Using comprehensive proteomics with strong cation exchange fractionation, we detected proteins in these LF samples. KGaA, Weinheim.
Increased sorbitol levels in the hypertrophic ligamentum flavum of diabetic patients with lumbar spinal canal stenosis.
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Juvenile dating ossifying fibroma of the neurocranium. Report of four cases. Juvenile psammomatoid ossifying fibroma JPOF is a benign dating lesion predominantly arising within the paranasal sinuses in children and young adults. Amazon occurrence is exceedingly rare and a abdelkader within the single portion of the married bone khaldi not been described. The authors report on one case of sinonasal JPOF secondarily extending into the coach cavity engaged three dating sites in memphis tn google maps primarily yama the neurocranial bones to increase clinical awareness of this uncommon tumor, which may be easily mistaken for meningioma. Moreover, the absence of activating missense mutations of the GNAS1 gene in two cases strongly argues against a relationship between JPOF and fibrous dysplasia. Cemento- ossifying fibroma. The cemento- ossifying fibroma is classified as a fibro-osseous lesion of the jaws. It commonly presents as a progressively growing lesion that can attain an enormous size with resultant deformity if left untreated. A case of cemento- ossifying fibroma involving the left mandible is described in a 35 year old female patient. The clinical, radiographic and histological features as well as surgical findings are presented. The cemento- ossifying fibroma is a central neoplasm of bone as well as the periodontium which has caused considerable controversy because of the confusion regarding terminology and the criteria for its diagnosis. PubMed Central.
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Ossified ligamentum flavum causing neurological deficit above the level of post-tuberculous kyphotic deformity. Late onset paraplegia is a rare complication of spinal tuberculosis. Disease reactivation and cord compression by internal gibbus are the common causes for neurological deficit. We report a patient with post-tubercular kyphotic deformity in whom the late onset paraplegia is caused by ossified ligamentum flavum above the level of kyphotic deformity. The deficit was attributable to the ossified ligamentum flavum and she recovered completely following posterior decompression and instrumented posterolateral fusion.
Some lines published in the official Bulletin of September 5th, specified that a dahir royal decree of Mohammed VI allowed to naturalize, exceptionally: Mr Khaled Hadj Brahim, born on February 29th, in Oran, in Algeria. Khaled was married to Samira, native of Oujda — the most Algerian of Moroccan estates-. It was she who urged him to militate for this double nationality. After the adoption of the law authorizing gay marriage in France, she asked me to return in Morocco and we have just moved. They met each other in They soon got along well.